Supplementary data files to the manuscript ‘A vaccine central in A(H5) influenza antigenic space confers broad immunity ’ by Kok et al. (2025).
Supplementary Data 1 - A(H5) HA maximum likelihood phylogenetic tree.
Supplementary Data 2 - Three-dimensional A(H5) influenza antigenic map.
Supplementary Data 3 - Validation of the A(H5) antigenic map.
Supplementary Data 4 - The effect of removing single individual antigens and sera on the map geometry.
Supplementary Data 5 - A(H5) antigenic maps highlighting WHO candidate virus vaccines and antigens used in the ferret vaccination studies.
Supplementary Data 6 - Merged antibody profiles upon vaccination with whole-inactivated vaccines containing engineered HA antigens.
Supplementary Data 7 - Individual antibody profiles upon vaccination with whole-inactivated vaccines containing engineered HA antigens.
Supplementary Data 8 - Merged antibody profiles of upon vaccination with split-inactivated vaccines containing wild-type HA antigens or the antigenically central HA antigen.
Supplementary Data 9 - Individual antibody profiles of animals from the Giza vaccination-challenge study.
Supplementary Data 10 - Individual antibody profiles of animals from the Sichuan vaccination-challenge study.
Note: interactive displays, especially Supplementary Data 3, might take a while to load. Supplementary Data 9 and 10 might not be properly displayed using the Chrome browser, hence Firefox is recommended.
Supplementary data corresponding to the initial submission can be found here.